Biofunctional Peptide FNIII14: Therapeutic Potential

Biofunctional peptide FNIII14, which is derived from the 14th fibronectin (FN) type III-like (FN-III) repeat of FN molecule, capable inhibiting cell adhesion to extracellular matrix (ECM). This functional site usually buried within molecular structure FN, but can be exposed by conformational changes and proteolytic cleavage. Peptide FNIII14 induce a change in β1-integrin active inactive form, causing inactivation. Based on this anti-adhesive activity, exhibits therapeutic potential for several diseases such as metabolic diseases, organ fibrosis, malignant tumors. blocks integrin-mediated signaling mechanism entirely distinct that conventional antagonisitic peptides, including Arg-Gly-Asp peptides competitively inhibit ECM binding integrin.